Computational Investigation of GluN2B Receptor Effectiveness of Octreotide in Nervous Diseases by Using AutoDock Vina

: The N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate that participate in excitatory postsynaptic signaling the mammalian central nervous system. In 1980s, octreotide first became available for treatment of acromegaly. acromegaly patients and healthy volunteers, somatostatin its analogs, such as lanreotide, dramatically decrease release GH. this study, we investigated effect octreotide, which controls blood lipids, on one proteins involved epilepsy. After examining genes epilepsy by DisGeNET server, selected receptor NMDA type subunit 2B gene with symbol GRIN2B. docking molecular simulation process was done using AutoDock Vina 1.2.0 algorithm under Chimera user interface. analysis results has been PDBsum Protein-Ligand Interaction Profiler servers. VMD program prepared images. Pocket Drug server detected eighteen packets. Only 5 out 18 pockets were acceptable. found target protein after simulations; 13 have fewer than 14 residues, more residues. We best (P35, P64), (P10, P14, P17).